Division of Allergy and Immunology

The Division of Allergy and Immunology at Children’s Hospital of Philadelphia (CHOP) provides comprehensive evaluation and treatment of immunologically mediated diseases. We are one of the largest pediatric allergy and immunology groups in the United States, and we care for patients from around the world.

Allergic Disorders

Allergies can be frustrating and scary. Our group provides supportive care for the most difficult allergies, with innovative approaches and a holistic approach. We treat skin allergies, asthma, and reactions to medications using the most up-to-date methods.

Our experts offer management of difficult-to-control allergic disorders with comprehensive care. We also provide care for those with anaphylactic reactions and angioedema.

Food Allergy

Children’s Hospital of Philadelphia hosts one of the largest centers that study all types of food allergy, including anaphylaxis, eosinophilic esophagitis, and food protein induced enterocolitis.  We have been designated as Center of Excellence by the Food Allergy Research and Education (FARE) organization. We provide all diagnostic testing including skin testing, blood tests, and diagnostic food challenges. We are also involved in clinical research protocols on food desensitization by multiple routes.

Center for Eosinophilic Esophagitis Disorders

Eosinophilic Esophagitis (EoE) was unknown 30 years ago, but today, diagnoses of this disorder are increasing rapidly. EoE causes chronic gastrointestinal symptoms ranging from pain to food impaction. Children’s Hospital of Philadelphia currently treats 1,700 infants, children and teenagers with EoE from around the globe — the largest clinical population in the world. The care we provide allows children to return to normal life. CHOP is also a member of the NIH-supported Consortium for Eosinophilic Gastrointestinal Research.

Food Protein Induced Enterocolitis

Food protein induced enterocolitis (FPIES) presents in infancy with delayed vomiting after eating trigger foods or failure to thrive. CHOP has the only dedicated center for FPIES in the world. We provide comprehensive care with the combined expertise of gastroenterology, nutrition and allergy.

Drug Allergies

Drug allergies can complicate therapy, compromise optimal care, and can be life threatening.  Our team provides education, desensitization when necessary, and improved overall medical treatment.


Asthma is one of the most common allergic conditions and can affect a child’s capacity to sleep, play and learn. Uncontrolled asthma can lead to emergency room visits and hospitalizations. Our team provides comprehensive care of asthma, individualizing treatment for every child whose life might be affected by this condition. Our team also specializes in the management of severe asthma, providing access to state-of-the-art biologic therapy and collaborating with other specialists at CHOP to optimize care and give every child the best opportunity to thrive.

Immune Deficiency

The Immune Deficiency Clinic at Children’s Hospital of Philadelphia is one of the largest in the world, treating patients with complex, rare immune deficiencies. Frequent infections, autoimmune diseases, and unusual or severe infections are common conditions that we treat. We are a Modell Center of Excellence and a Pediatric Immune Deficiency Treatment Consortium (PIDTC) transplant center. We collaborate nationally and internationally to ensure the best care for children with these rare diseases.

Featured Faculty

Soma Jyonouchi, MDSoma Jyonouchi, MD

Soma Jyonouchi, MD, is an attending physician in the Division of Allergy, Immunology Service, and Center for Cornelia de Lange Syndrome and Related Diagnoses at Children's Hospital of Philadelphia.

Areas of expertise: immunodeficiency in Cornelia de Lange syndrome and other genetic syndromes, asthma

Jonathan Spergel, MD, PhDJonathan Spergel, MD, PhD

Jonathan Spergel, MD, PhD, is the Co-director of the Center for Pediatric Eosinophilic Disorders and the Chief of the Allergy Section.

Areas of expertise: allergies and asthma, atopic dermatitis, eosinophilic esophagitis, food allergy

Kathleen Sullivan, MD, PhDKathleen Sullivan, MD, PhD

Kathleen Sullivan, MD, PhD, is Chief of the Division of Allergy and Immunology.

Areas of expertise: the genetics of systemic lupus erythematosus (SLE), care of immunodeficient patients, protection of immunologically vulnerable patients, hemophagocytic lymphohistiocytosis(HLH), early onset IBD, DiGeorge syndrome, 22q11.2 deletion syndrome

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Global Patient Services is a program within the Department of Global Medicine at Children's Hospital of Philadelphia.